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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SEC24C All Species: 11.21
Human Site: Y278 Identified Species: 17.62
UniProt: P53992 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53992 NP_004913.2 1094 118325 Y278 H S P Q Q P G Y Q P Q Q N G S
Chimpanzee Pan troglodytes XP_001145058 1094 118246 Y278 H S P Q Q P G Y Q P Q Q N G S
Rhesus Macaque Macaca mulatta XP_001104565 998 107625 S249 S Q P N H V S S P P P Q A L P
Dog Lupus familis XP_850963 1096 118584 G279 M H S S Q Q P G Y Q L Q Q N G
Cat Felis silvestris
Mouse Mus musculus Q3U2P1 1090 118764 K281 Q L V N Q N P K T S R S V G S
Rat Rattus norvegicus NP_001102926 1095 118506 G278 M H S P Q Q P G Y Q L Q Q N G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513100 1030 112379 T279 V I E N D K A T R A G Q V Y F
Chicken Gallus gallus XP_421617 1147 124543 Y335 T H P P Q P G Y Q M Q Q N G S
Frog Xenopus laevis NP_001087832 1126 123503 P278 A S P N Q A Q P P M P G V P L
Zebra Danio Brachydanio rerio XP_700597 1315 142554 S278 P Q A P P S V S Q Q S F P Q A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392952 1276 140829 Q388 Q S S L I N Q Q G F N R P S M
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783728 1150 123558 G321 P A T P P G T G P P G P P G M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M081 1080 116273 A287 G P P S A Q V A P P L G F P G
Baker's Yeast Sacchar. cerevisiae P53953 876 98925 S127 K A V P K T N S L L K K T K L
Red Bread Mold Neurospora crassa Q7S4P3 950 103512 P201 V A E L E L P P P P I I L P P
Conservation
Percent
Protein Identity: 100 99.5 86.9 94.8 N.A. 26.9 92 N.A. 51.9 75.4 69 59.5 N.A. N.A. 44.5 N.A. 52.6
Protein Similarity: 100 99.7 87.9 96.1 N.A. 45.8 94.4 N.A. 66.2 82.3 78.1 69 N.A. N.A. 59.4 N.A. 64.3
P-Site Identity: 100 100 20 13.3 N.A. 20 13.3 N.A. 6.6 73.3 20 6.6 N.A. N.A. 6.6 N.A. 13.3
P-Site Similarity: 100 100 20 13.3 N.A. 26.6 13.3 N.A. 13.3 73.3 20 13.3 N.A. N.A. 13.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 33 22.4 30
Protein Similarity: N.A. N.A. N.A. 49.3 41.1 47
P-Site Identity: N.A. N.A. N.A. 13.3 0 6.6
P-Site Similarity: N.A. N.A. N.A. 13.3 26.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 20 7 0 7 7 7 7 0 7 0 0 7 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 14 0 7 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 7 0 7 7 0 7 % F
% Gly: 7 0 0 0 0 7 20 20 7 0 14 14 0 34 20 % G
% His: 14 20 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 7 0 0 0 0 0 7 7 0 0 0 % I
% Lys: 7 0 0 0 7 7 0 7 0 0 7 7 0 7 0 % K
% Leu: 0 7 0 14 0 7 0 0 7 7 20 0 7 7 14 % L
% Met: 14 0 0 0 0 0 0 0 0 14 0 0 0 0 14 % M
% Asn: 0 0 0 27 0 14 7 0 0 0 7 0 20 14 0 % N
% Pro: 14 7 40 34 14 20 27 14 34 40 14 7 20 20 14 % P
% Gln: 14 14 0 14 47 20 14 7 27 20 20 47 14 7 0 % Q
% Arg: 0 0 0 0 0 0 0 0 7 0 7 7 0 0 0 % R
% Ser: 7 27 20 14 0 7 7 20 0 7 7 7 0 7 27 % S
% Thr: 7 0 7 0 0 7 7 7 7 0 0 0 7 0 0 % T
% Val: 14 0 14 0 0 7 14 0 0 0 0 0 20 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 20 14 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _